2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

Related Products

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0023R
    Azelnidipine (Standard)
    		Inhibitor
    Azelnidipine (Standard) is the analytical standard of Azelnidipine. This product is intended for research and analytical applications. Azelnidipine (CS 905; Calblock) is a dihydropyridine derivative, an L-type calcium channel blocker, and can fight hypertension.
    Azelnidipine (Standard)
  • HY-B0758R
    Troxipide (Standard)
    Troxipide (Standard) is the analytical standard of Troxipide. This product is intended for research and analytical applications. Troxipide is an orally active defensive factor-enhancing therapeutic agent for gastritis and gastric ulcer (GU). Troxipide is a non-antisecretory gastro protective agent with antiulcer, anti-inflammatory and mucus-secreting properties.
    Troxipide (Standard)
  • HY-19053
    NP-252
    		Antagonist
    NP-252 is a calcium channel antagonist with an 20% effective dose (ED20) of 2.55 mg/kg in spontaneously hypertensive rats.
    NP-252
  • HY-B1971S1
    Deltamethrin-d6
    Deltamethrin-d6 (Decamethrin-d6) is deuterium labeled Deltamethrin. Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control.
    Deltamethrin-d<sub>6</sub>
  • HY-U00151A
    Dopropidil hydrochloride
    		Antagonist
    Dopropidil hydrochloride is a novel anti-anginal calcium ion modulating agent, possessing intracellular calcium antagonist activity and anti-ischemic effects in several predictive animal models.
    Dopropidil hydrochloride
  • HY-N0607R
    Ginsenoside Ro (Standard)
    		Antagonist
    Ginsenoside Ro (Standard) is the analytical standard of Ginsenoside Ro. This product is intended for research and analytical applications. Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a Ca2+-antagonistic antiplatelet effect with an IC50 of 155 μM. Ginsenoside Ro reduces the production of TXA2 more than it reduces the activities of COX-1 and TXAS.
    Ginsenoside Ro (Standard)
  • HY-121701
    SR33805 analog
    		Antagonist
    SR 33805 (analog) is an orally active Ca2+ channel blocker that selectively inhibits the proliferation of smooth muscle cells. SR 33805 (analog) reduces calcium uptake by blocking calcium channels, thereby inhibiting smooth muscle cell proliferation induced by serum, platelet-derived growth factor, and basic fibroblast growth factor. SR 33805 (analog) significantly reduces intimal thickening following endothelial injury in rabbits. SR 33805 (analog) shows promise for cardiovascular disease research, such as in early atherosclerosis.
    SR33805 analog
  • HY-164466
    CAD204520
    		Inhibitor
    CAD204520, a SERCA inhibitor (IC50 = 0.34 μM), targets mutated over wild type NOTCH1 proteins in T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL).
    CAD204520
  • HY-B0284S2
    Nifedipine-13C8
    		Antagonist
    Nifedipine-13C8 is a deuterated labeled Nifedipine. Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.
    Nifedipine-<sup>13</sup>C<sub>8</sub>
  • HY-19662
    Cronidipine
    		Inhibitor
    Cronidipine (LF2-0254) is a Calcium Channel blocker. Cronidipine can be used in cardiovascular disease related research.
    Cronidipine
  • HY-165634
    (R)-Azelnidipine
    		Antagonist
    (R)-Azelnidipine is a highly lipophilic Calcium Channel antagonist with high affinity for vascular walls and antihypertensive activity. (R)-Azelnidipine shows potential for use in cardiovascular disease research.
    (R)-Azelnidipine
  • HY-120535
    RS 30026
    		Agonist
    RS 30026 is a potent calcium channel agonist with a pEC50 value of 7.45.
    RS 30026
  • HY-116072
    Antiarrhythmic agent-2
    		Inhibitor
    Antiarrhythmic agent-2 is a nonspecific Ca2+ inward current blocker that inhibits ionic currents in sensory neuron membranes. Antiarrhythmic agent-2 can be used in the study of cardiovascular diseases, such as arrhythmias.
    Antiarrhythmic agent-2
  • HY-122201
    NSC156529
    		Antagonist
    NSC156529 is a potent T-type calcium-channel antagonist. NSC156529 shows inhibits on Cav3.1 and Cav3.2 and o Cav3.3 without effect. NSC156529 has the potential for the research of neuropsychic and genital system diseases.
    NSC156529
  • HY-B0166AR
    L-Ascorbic acid (sodium salt) (Standard)
    		Inhibitor
    L-Ascorbic acid (sodium salt) (Standard) is the analytical standard of L-Ascorbic acid (sodium salt). This product is intended for research and analytical applications. L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor.
    L-Ascorbic acid (sodium salt) (Standard)
  • HY-B0265R
    Nimodipine (Standard)
    		Inhibitor
    Nimodipine (Standard) is the analytical standard of Nimodipine. This product is intended for research and analytical applications. Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders.
    Nimodipine (Standard)
  • HY-B1090R
    Cinnarizine (Standard)
    		Inhibitor
    Cinnarizine (Standard) is the analytical standard of Cinnarizine. This product is intended for research and analytical applications.
    Cinnarizine (Standard)
  • HY-14275S
    Verapamil-d3
    		Antagonist
    Verapamil-d3 ((±)-Verapamil-d3) is deuterium labeled Verapamil. Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research.
    Verapamil-d<sub>3</sub>
  • HY-W788583
    Inositol 1,3-bisphosphate sodium
    Inositol 1,3-bisphosphate sodium is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals.
    Inositol 1,3-bisphosphate sodium
  • HY-118136
    CGP 28392
    		Activator
    CGP 28392 is an activator for calcium channel, and reactivates the oxygen evolution in calcium-deficient photosystem II (PS II) particles.
    CGP 28392
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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